瘦素及脂联素在消化系统肿瘤中的研究进展

Progress of leptin and adiponectin in digestive system neoplasms

作为心脑血管疾病、癌症、糖尿病等慢性病的重要诱因，肥胖已被世界卫生组织列为继心脑血管疾病和癌症之后威胁人类健康的第三大敌人。近年来的研究结果显示，肥胖与结直肠癌、食管癌、肾癌和子宫内膜癌等许多肿瘤的发生相关。但其导致肿瘤发生风险增加的机制尚未完全揭示。瘦素、脂联素是脂肪组织分泌的一类激素，参与机体能量代谢，在影响肿瘤生长的多个环节日益受到重视。

As an important incentive for cardiovascular disease, cancer, diabetes and other chronic diseases, obesity after cardiovascular disease and cancer has been listed as the third largest threat to human health by World Health Organization. Recent research has shown that obesity is associated with coloreetal cancer, esophageal cancer, kidney cancer, endometrial cancer, however, it has not been fully disclosed that the mechanism could lead to an increased risk of tumors. Leptin and adiponectin are a kind of hormone secreted by adipose tissue, which involve in the energy metabolism, and play an increasing significant role in the tumors＂ affecting factors.