依替米星联合胸腺肽肠溶片治疗耐多药肺结核对疗效改善、肺功能及生活质量的影响

Effect of Efficacy,Lung Function and Life Quality of Etimicin Combined with Thymopeptide Enteric-coated Tablets in the Treatment of Multi-drug Resistant Pulmonary Tuberculosis

目的研究耐多药肺结核行依替米星和胸腺肽肠溶片联合治疗对患者疗效改善、肺功能及生活质量的影响。方法资料选取汕头市第三人民医院于2014-08—2015-08间收治的耐多药肺结核80例患者予以回顾性地分析,按照临床所用不同治疗方案分成2组,将行常规方案治疗34例患者作为对照组,将行依替米星和胸腺肽肠溶片联合治疗46例患者作为观察组,对两组疗效改善、肺功能及生活质量情况进行对比。结果观察组治疗后半年痰菌转阴率80.43%比对照组61.76%高,且总不良反应率4.35%比对照组23.53%低(P<0.05);观察组在两组治疗后肺功能与生活质量指标均改善基础上,其改善幅度均比对照组显著(P<0.05,P<0.01)。结论耐多药肺结核患者行依替米星和胸腺肽肠溶片联合治疗能够改善疗效与肺功能,且提高患者生活质量,具有推广及应用价值。

Objective To study the effect of improvement of curative effect lung function and life quality of patients of Etimicin combined with Thymopeptide Enteric-Coated Tablets in the treatment of multi-drug resistant pulmonary tuberculosis. Methods The clinical data of 80 patients with multi-drug resistant pulmonary tuberculosis who received treatment in the hospital from August,2014 to August,2015 were reviewed. These patients were divided into two groups according to different clinical programs,with 34 patients given routine treatment as the control group and the other 46 given Etimicin and Thymopeptide Enteric-Coated Tablets as the observation group. The improvement of the efficacy,lung function and life quality in the two groups were compared. Results The sputum negative conversion rate in the observation group was 80. 43%,which was higher than the 61. 76% in the control group. The total incidence of adverse reactions in the observation group was 4. 35%,which was lower than the 23. 53% in the control group（ P〈0. 05）. After treatment,the lung function and life quality index were improved in both groups. And the improvement in the observation group was more obvious than that in the control group（ P〈0. 05,P〈0. 01）. Conclusion Etimicin combined with Thymopeptide Enteric-coated Tablets can improve the efficacy,pulmonary function and life quality of patients with multi-drug resistant pulmonary tuberculosis,which is therefore worthwhile to be popularized in clinical application.