吸烟对原发性肝癌患者凝血功能的影响

Infection of smoking on blood coagulation of primary liver cancer

目的探讨吸烟对原发性肝癌患者凝血功能的影响。方法 97例确诊为原发性肝癌的初诊患者,根据吸烟指数不同分为1组（吸烟指数为0,26例）,2组（吸烟指数为1~199,21例）,3组（吸烟指数为200~399,22例）,4组（吸烟指数为〉400,28例）。对比四组的C反应蛋白（CRP）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、D-二聚体（D-D）、血小板计数（PLT）。结果 1组和2组、3组和4组患者之间的PLT、PT、APTT、D-D、FIB、CRP检验指标比较,差异均无统计学意义（P〉0.05）。1、2合并组PT、APTT高于3、4合并组,PLT、D-D、FIB、CRP低于3、4合并组,差异均具有统计学意义（t=9.930、2.578、548.266、3.977、4.594、118.708,P〈0.05）。结论长期吸烟可介导肝癌患者长期处于慢性炎症反应状态,并影响原发性肝癌患者的凝血功能。

Objective To explore influence of smoking on blood coagulation of primary liver cancer. Methods A total of 97 patients diagnosed primary liver cancer were divided by different smoking indexes into group 1（smoking index as 0, 26 cases）, group 2（smoking index as 1~199, 21 cases）, group 3（smoking index as 200~399, 22 cases） and group 4（smoking index 400, 28 cases）. Comparison were made on C-reactive protein（CRP）, prothrombin time（PT）, activated partial thromboplastin time（APTT）, fibrinogen（FIB）, D-dimer（D-D） andblood platelet count（PLT）. Results There was no statistically significant difference of PLT, PT, APTT, D-D, FIB and CRP between group 1 and group 2, group 3 and group 4（P〈0.05）. Group 1 and group 2 had higher PT and APTT than group 3 and group 4, lower PLT, D-D, FIB and CRP than group 3 and group 4, and the difference had statistical significance（t=9.930, 2.578, 548.266, 3.977, 4.594, 118.708, P〈0.05）. Conclusion Long-term smoking can mediate liver cancer patients in chronic inflammation state and affect blood coagulation of primary liver cancer.