噻托溴铵粉联合布地奈德福莫特罗吸入治疗支气管哮喘-慢性阻塞性肺疾病重叠综合征的短期疗效观察

Observation on short-term curative effect of bronchial asthma and chronic obstructive pulmonary disease overlap syndrome treated by tiotropium bromide powder combined with symbicort turbulaler inhalation

目的观察支气管哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)应用噻托溴铵粉联合布地奈德福莫特罗吸入治疗的短期疗效。方法 78例支气管哮喘-慢性阻塞性肺疾病重叠综合征患者,随机分为实验组和对照组,每组39例。实验组采用噻托溴铵粉联合布地奈德福莫特罗吸入治疗,对照组采用布地奈德福莫特罗吸入治疗。观察临床治疗效果,对比治疗前后两组患者的肺功能。结果治疗4周后,实验组总控制有效率92.3%高于对照组74.4%,差异具有统计学意义(P<0.05)。治疗前两组患者第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC、一氧化碳弥散量(DLCO)比较差异均无统计学意义(P>0.05);治疗后实验组患者FEV1、FVC、FEV1/FVC、DLCO均高于对照组,差异均具有统计学意义(P<0.05)。结论支气管哮喘-慢性阻塞性肺疾病重叠综合征患者应用噻托溴铵粉联合布地奈德福莫特罗吸入治疗时,短期疗效较好,可明显改善患者肺功能,促进患者生活质量的提升,可在临床进一步推广。

Objective To observe short-term curative effect of bronchial asthma and chronic obstructive pulmonary disease overlap syndrome（ACOS）treated by tiotropium bromide powder combined with symbicort turbulaler inhalation. Methods A total of 78 patients with bronchial asthma and chronic obstructive pulmonary disease overlap syndrome were randomly divided into experimental group and control group, with 39 cases in each group. The experimental group received tiotropium bromide powder combined with symbicort turbulaler inhalation for treatment, and control group received symbicort turbulaler inhalation for treatment. Observation and comparison were made on clinical effect and lung function before and after treatment in two groups. Results The experimental group had higher total control effective rate as 92.3% than 74.4% in control group, and the differencehad statistical significance（P〈0.05）. There were no statistically significant differences in forced expiratory volume in 1 second（FEV1）, forced vital capacity（FVC）, FEV1/FVC and diffusion capacity of carbon monoxide（DLCO） before treatment in two groups（P〉0.05）. The experimental group had higher FEV1, FVC, FEV1/FVC and DLCO than control group,, and the difference had statistical significance（P〈0.05）. Conclusion Tiotropium bromide powder combined with symbicort turbulaler inhalation provides good short-term curative effect in patients with bronchial asthma and chronic obstructive pulmonary disease overlap syndrome. This method also can improve lung function and promote life quality of patients. So this method can be further popularized in clinic.