初诊系统性红斑狼疮患者血清25羟维生素D与炎性细胞因子的相关性

Correlations between serum 25-hydroxyvitamin D and cytokines in patients newly diagnosed with systemic lupus erythematosus

目的探讨25羟维生素D(25-OH-VitD)在中国汉族初诊系统性红斑狼疮(SLE)患者外周血的水平及其与α2干扰素(IFN-α2)、白细胞介素6(IL-6)、IL-10和IL-17A的相关性。方法收集86例初诊SLE患者和73例健康对照组血清。分别采用ELISA检测25-OH-VitD,Luminex液相芯片技术检测IFN-α2、IL-6、IL-10和IL-17A水平。采用Spearman检验分析25-OH-VitD与细胞因子、临床表现及C3、24 h尿蛋白定量的相关性。结果 SLE患者血清25-OH-VitD水平明显低于对照组。SLE患者血清25-OH-VitD水平与补体C3水平正相关,与IL-17A水平和24 h尿蛋白定量水平负相关;而与IFN-α2、IL-6和IL-10无相关性。结论初诊SLE患者血清25-OH-VitD水平降低,并与IL-17A有负相关关系。

Objective To investigate the correlations between serum 25-hydroxyvitamin D （25-OH-VitD） and serum cytokines of interferon （IFN）-α2, intedeukin（IL）-6, IL-10, and IL-17A in Chinese Han patients newly diagnosed with systemic lupus erythematosus （SLE）. Methods This study recruited 86 Chinese patients newly diagnosed with SLE and 73 healthy volunteers. The serum 25-OH-VitD was detected using ELISA. The serum levels of IFN-α2, IL-6, IL-10 and IL-17A were detected using Luminex liquichip. The associations between serum 25-OH-VitD and serum cytokines, clinical manifestations and laboratory findings were analyzed using Spearman linear correlation analysis. Results The serum 25-OH-VitD was significantly lower in SLE patients than in healthy controls. The serum 25-OH-VitD was positively correlated with serum C3, negatively correlated with serum IL-tTA and 24 hour urine protein excretion, but not obviously correlated with serum IFN-α2, IL-6 and IL-10. Conclusion The serum 25-OH-VitD decreases in Chinese patients newly diagnosed with SLE and it is negatively correlated with serum IL-17A.