氨磺必利治疗精神分裂症阴性症状的临床效果观察

Observation on the clinical effect of Amisulpride in the treatment of schizophrenia patients without symptom

目的观察氨磺必利治疗精神分裂症阴性症状的临床疗效。方法选取住院72例以阴性症状为主的精神分裂症患者,随机分为研究组和对照组,各36例,研究组给予氨磺必利,对照组给予利培酮,均口服治疗8周,采用简明精神病量表(BPRS)及阴性量表(SANS)进行临床效果分析,采用症状量表(TESS)评定不良反应。结果氨磺必利组与利培酮组总体疗效相当,氨磺必利组控制阴性症状疗效优于利培酮组,且不良反应较轻。结论氨磺必利是临床上治疗以阴性症状为主的精神分裂症的理想药物。

Objective To observe the clinical effect of Amisulpride in the treatment of schizophrenia patients with negative symptoms. Methods A total of 72 hospitalized schizophrenia patients with negative symptoms were randomly divided into study group and control group,36 cases in each group. The study group was given amisulpride,risperidone was given to the patients in control group,and the treatment lasted for 8 weeks.The Brief Psychiatric Rating Scale（ BPRS） and negative symptom scale（ SANS） were used to analyze the clinical effect,the symptom scale（ TESS） was used to assess the adverse reactions. Results The overall efficacy of amisulpride group was similar to risperidone group. The curative effect of controlling negative symptoms in amisulpride group was superior to risperidone group,as well as mild adverse reactions. Conclusions The amisulpride is an ideal drug in the treatment of schizophrenia patients with negative symptoms.