老年人颈动脉粥样硬化斑块形成的临床相关危险因素分析

Analysis on relevant risk factors of carotid atherosclerotic plaque formation in the elder

目的探讨老年人颈动脉粥样硬化斑块形成与临床多种危险因素的相关性。方法 922例老年人按颈动脉彩超检查结果分为有斑块组和无脉斑块组,进行多种危险因素(如年龄、血压、BMI、胆固醇、血脂、血尿酸、血糖、糖化血红蛋白)统计学和二项分类Logistic回归分析。结果两组老年人的年龄、收缩压、舒张压、血糖、糖化血红蛋白、血肌酐比较差异有统计学意义(P<0.05),而BMI、胆固醇、血脂、血尿酸差异无统计学意义(P>0.05)。将颈动脉斑块有无作为因变量,入选有显著性意义的变量年龄、收缩压、舒张压、血糖、糖化血化蛋白、血肌酐作为自变量,进行二项分类Logistic回归分析,结果对颈动脉斑块形成有显著影响的变量年龄是独立的危险因素。结论老年人颈动脉粥样硬化斑块形成受年龄、收缩压、舒张压、血糖、糖化血红蛋白、血肌酐的影响,其中年龄是独立的危险因素。

Objective To investigate the correlation between the occurrences of carotid atherosclerotic plaque formation and multiple clinical risk factors in the senile. Methods 922 cases of the senile were divided into carotid plaques group and non-carotid plaques group. The risk factors（ such as age,blood pressure,BMI,cholesterol,blood lipid,blood glucose,glycosylated hemoglobin,blood uric acid） were evaluated by statistics and binomial Logistic regression analysis.Results There were significantly differences in age,systolic pressure,diastolic blood pressure,blood sugar,glycosylated protein and serum creatinine in the two groups（ P〈0. 05）.There were no differences of BMI,cholesterol,blood fat（ P〈0. 05）. Age,systolic pressure,diastolic blood pressure,blood sugar,glycosylated protein,serum creatinine were analyzed by binomial logistic regression analysis. Age was an independent risk factor of carotid atherosclerotic plaque formation in the senile（ P〈0.05）.Conclusions The formation of senile carotid atherosclerotic plaque is influenced by age,systolic pressure,diastolic blood pressure,blood sugar,glycosylated protein and serum creatinine. Age could be the independent risk factor.