透明质酸凝胶与他克莫司软膏治疗面部脂溢性皮炎疗效观察

Clinical efficacy of hyaluronic acid gel and tacrolimus ointment in the treatment of facial seborrheic dermatitis

目的分别探讨透明质酸凝胶和他克莫司软膏治疗面部脂溢性皮炎的疗效、安全性和对皮肤屏障功能的影响。方法 89例面部脂溢性皮炎患者随机分为试验组和对照组。试验组外用透明质酸凝胶,对照组外用他克莫司软膏,在0、7、14、28 d进行随访,每次随访用VISIA皮肤图像分析仪观察面部红色区,评估患者病情,并测定皮肤屏障功能相关指标。结果疗程结束后,试验组和对照组显效率分别为82.2%和86.4%,差异无统计学意义(P>0.05);试验组和对照组角质层含水量分别为(56.60±9.54)和(55.14±11.57),两组差异无统计学意义(P=0.610);试验组和对照组经表皮水分丢失值分别为[(19.37±5.18)g/(m^2·h)]、[(25.10±14.0)g/(m^2·h)],两组差异无统计学意义(P=0.142)。结论透明质酸凝胶治疗面部脂溢性皮炎疗效与他克莫司软膏同样有效,透明质酸凝胶能改善皮肤屏障功能,减轻皮损,使用安全,耐受性好,值得临床推广。

Objective To investigate the effect and safety of hyaluronic acid gel and tacrolimus ointment on facial seborrheic dermatitis and the effect of hyaluronic acid gel and tacrolimus ointment on skin barrier function. Methods A total of 89 female outpatients with facial seborrheic dermatitis were randomly divided into two groups which were treated with hyaluronic acid gel（experiment group, n=45） or tacrolimus ointment（control group, n=44） respectively for 28 days. All subjects were followed-up on 7, 14 and 28 days in the process of treatment. Results There was no difference in the therapeutic effect between the experiment group and the control group after 28 days（P〉0.05）. Conclusion Hyaluronic acid gel has the similar efficacy of tacrolimus ointment in the treatment of facial seborrheic dermatitis. Hyaluronic acid gel could alleviate skin lesion and improve skin barrier function in the treatment of facial seborrheic dermatitis, which may be a good choice for combination therapy of facial seborrheic dermatitis.