固有淋巴样细胞2亚类与炎症性皮肤病

The role of innate lymphoid cells in inflammatory dermatosis

近年来新发现的一群表达CD45、具有淋巴细胞表型特征,但缺乏适应性免疫特有抗原特异性表面受体的免疫细胞,该群细胞被命名为固有淋巴样细胞(innate lymphoid cells,ILCs)。根据刺激因子、转录因子表达及产生效应因子的不同,ILCs可分为3类亚型,现有研究表明ILCs是淋巴器官发生、代谢的关键,也是组织稳态维持、修复,以及机体抵抗病毒、蠕虫感染的基础。此外ILCs也在皮肤中表达,并参与了皮肤创伤、特应性皮炎、接触性皮炎等皮肤炎症。

A novel family of CD45 expressing haematopoietic effector cells（innate lymphoid cells, ILCs） has been identifi ed. These cells have phenotypical features of lymphoid cells but lack of antigen specifi c surface acceptor of adaptive immunity. The ILCs family can be divided into three subtypes based on the activating cytokines, expression of transcription factors and production of effector cytokines. Many studies have demonstrated that ILCs are essential for genesis of lymphoid organs and metabolism, and these cells are also important to tissue homeostasis and repair, as well as protection against viral and helminth infections. In addition, ILCs are expressed in skin as well and take a role in the pathogenesis of skin wound repairing, atopic dermatitis and allergic contact dermatitis.