酸枣仁提取物改善小鼠睡眠的研究

Study on the Effect of Semen Ziziphi Spinosae Extract on Sleep Improvement of Mice

目的观察酸枣仁提取物对改善小鼠睡眠的影响。方法通过直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验、巴比妥钠睡眠潜伏期实验来测定动物睡眠情况。结果酸枣仁提取物中、高剂量组能延长戊巴比妥钠诱导的小鼠的睡眠时间,与对照组比较差异有统计学意义(P<0.05),以中剂量效果更佳;可缩短巴比妥钠诱导的小鼠的入睡潜伏期,与对照组比较差异有统计学意义(P<0.05)与,以中剂量效果更佳;且无直接睡眠作用。酸枣仁提取物对小鼠的体重增长无影响。结论酸枣仁提取物具有改善小鼠睡眠作用。

OBJECTIVE To observe the impact of Semen Ziziphi Spinosae Extract on the sleeping improvement in mice. METHODS Sleeping movement in mice were determined by the direct sleeping experiment,prolonged pentobarbital sodium sleeping experiment,hypnotic experiment under the threshold dosage of pentobarbital sodium,sleeping incubation experiment of barbital sodium. RESULTS Compared to the control group,the prolonged sleeping time of mice induced by pentobarbital sodium and the decreased sleeping incubation induced by barbital sodium could be statistically significant（ P〈0. 05） in the medium and high dosage group,the effect of medium dosage group were better than the other group. There were no impact were observed toward the directed sleeping and weigh in mice. CONCLUSION Semen Ziziphi Spinosae Extract could improve the sleeping quality in mice.