奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的临床分析

Clinical Analysis of Octreotide Combined with Thrombin in the Treatment of Hepatocirrhosis with Upper Gastrointestinal Bleeding

目的探究奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的治疗效果。方法选择2012年6月~2015年6月我院收治的98例肝硬化合并上消化道出血患者,随机分为两组,即观察组经奥曲肽联合凝血酶治疗,对照组仅经奥曲肽治疗。结果治疗后观察组总有效率显著高于对照组（P〈0.05）;观察组止血时间为（19.4±3.1）h,住院时间为（4.4±1.2）d,输血量为（214.2±44.7）m L,再出血率为8.2%均显著低于对照组（P〈0.05）。结论经奥曲肽联合凝血酶治疗肝硬化合并上消化道出血,可有效止血,控制再出血,效果显著,值得临床推广采用。

OBJECTIVE To investigate the clinical efficacy for octreotide combined with thrombin in the treatment of cirrhosis with upper gastrointestinal bleeding. METHODS Selection of 98 cases of cirrhosis combined with upper gastrointestinal bleeding in our hospital from June 2012-June 2015,were randomly divided into two groups,the observation group after treatment of octreotide combined with thrombin,the control group only after octreotide treatment. RESULTS after treatment,the total effective rate of the observation group was significantly higher than that of the control group（ P〈0. 05）; observation group bleeding time was（ 19. 4 ± 3. 1） h,the length of time was（ 4. 4 ±1. 2） d,the volume of blood transfusion was（ 21. 42 ＋ 44. 7） m L,rebleeding rate was 8. 2% were significantly lower than those of the control group（ P〈0. 05）. CONCLUSION The effect of octreotide combined with thrombin in the treatment of cirrhosis with upper gastrointestinal bleeding,which can effectively stop bleeding,control bleeding,and then,the effect is significant,worthy of clinical use.