实脾饮合真武汤加减治疗小儿肾病综合征的临床研究

Clinical research of spleen decoction combined with Zhenwu decoction in treatment of nephrotic syndrome in children

目的研究实脾饮合真武汤加减治疗小儿肾病综合征的临床疗效。方法选择我院于2011年1月~2015年8月期间收治的50例肾病综合征患儿为研究对象,采用随机数表法将其分为观察组和对照组,每组各25例。对照组进行常规西医治疗,观察组在对照组的基础上加用实脾饮合真武汤加减治疗。比较两组患儿治疗后的生化指标变化、感染及复发情况。结果两组患儿胆固醇、三酰甘油、白蛋白及尿蛋白治疗后与治疗前相比均有明显改善,差异有统计学意义（P〈0.05）,而治疗前、后两组之间相比均无明显差异（P〉0.05）;对照组患儿各系统的感染发生率明显高于观察组,且治疗半年后的复发率也高于观察组,差异有统计学意义（P〈0.05）。结论小儿肾病综合征采用实脾饮合真武汤加减治疗临床疗效较好,可有效减少治疗过程中的不良反应,减少复发情况,具有较高的临床应用价值。

Objective To explore the clinical effect of spleen decoction combined with Zhenwu decoction in treatment of nephrotic syndrome in children. Methods 50 cases of children with nephrotic syndrome cured in our hospital from January 2011 to Auguest 2015 were selected as the study objects. According to the random digital table method, they were divided into observation group and control group with 25 cases in each. Childeren in control group were treated with conventional western medicine, and children in observation group were treated with spleen decoction combined with Zhenwu decoction on the basis of conventional western medicine. Biochemical changes, infection and relapse after treatment of the two groups were compared. Results The levels of cholesterol, triglyceride, albumin and urinary protein in the two groups were significantly improved after treatment, compared with before treatment, and the difference was statistically significant（P〈0.05）. However, there was no significant difference between the two groups before and after treatment（P〉0.05）. The incidence of infection in control group was significantly higher than that in observation group（P〈0.05）. The recurrence rate in control group was also higher than that in observation group（P〈0.05）. Conclusion The clinical effect of spleen decoction combined with Zhenwu decoction in treatment of nephrotic syndrome in children is good. It can effectively reduce the adverse reactions in the course of treatment, and reduce the recurrence. It has a high clinical value.