足三里穴位注射异丙嗪治疗恶性肿瘤化疗后顽固性呕吐的疗效观察

Curative effect observation of zusanli acupoint injection of promethazine in treatment of refractory vomiting after chemotherapy for malignant tumor

目的探讨足三里穴位注射异丙嗪治疗恶性肿瘤化疗后顽固性呕吐的效果。方法选取我院2014年3月~2016年6月肿瘤化疗患者76例,在化疗期间,给予患者甲氧氯普胺肌肉注射预防呕吐,但仍出现顽固性呕吐,将两组患者随机分为对照组和观察组,每组38例,其中对照组在患者出现顽固性呕吐后继续给予其甲氧氯普胺静脉滴注止吐,观察组患者在出现顽固性呕吐后给予足三里穴位注射异丙嗪止吐,比较两组患者治疗后的治疗总有效率、并发症发生率和GQOLI评分。结果观察组患者治疗以97.37%的总有效率显著高于对照组患者,而且GQOLI评分中,其物质功能、躯体功能、心理功能和社会功能评分均明显高于对照组患者（P〈0.05）。观察组和对照组患者的并发症发生率对比,分别为5.26%和7.89%,差异无统计学意义（P〉0.05）。结论对于恶性肿瘤化疗后出现顽固性呕吐的患者,采取足三里穴位注射异丙嗪可显著提高患者的治疗总有效率以及生活质量,且不会明显增加其并发症。

Objective To explore the curative effect of zusanli acupoint injection of promethazine in treatment of refractory vomiting after chemotherapy for malignant tumor. Methods 76 cases of cancer chemotherapy patients cured in our hospital from March 2014 to June 2016 were selected as the study objects. During chemotherapy, all the patients were treated with intramuscular injection of methylene chloride to prevent vomiting, but there was still stubborn vomiting. The patients were randomly divided into control group and observation group with 38 cases in each. Patients in control group were treated with intravenous infusion of methylene chloride for patients with intractable vomiting. Patients in observation group were treated with zusanli acupoint injection of promethazine for patients with intractable vomiting. Total effective rate, complication rate and GQOLI score after the treatment of the two groups were compared. Results Total effective rate of observation group was 97.37%, which was significantly higher than that of control group. In GQLI scores, the physical function score, physical function score, psychological function score and social function score of observation group were significantly higher than those fo control group（P〈0.05）. Complication rates of the observation group and control group were 5.26% and 7.89% respectively, and the difference was not significant（P〈0.05）. Conclusion For patients with intractable vomiting after cancer chemotherapy, Zusanli injection of promethazine can significantly improve the treatment of patients with total efficiency and quality of life, and will not significantly increase its complications.