脑心通胶囊对脑血栓形成患者疗效的临床研究

Clinical study on the efficacy of Naoxintong capsule for cerebral thrombosis patients

目的观察脑心通胶囊在治疗脑血栓形成方面的作用;研究脑心通胶囊联合常规治疗与常规治疗的差异;观察脑心通胶囊对实验组患者血脂、血尿酸、同型半胱氨酸的影响。方法选择2015年4—10月期间在齐齐哈尔市第一医院神经内科及急诊内科住院治疗的脑血栓形成患者,随机分为实验组(脑血栓组)和对照组(常规治疗组),应用NIHSS量表给予患者评分,记录患者治疗前后血脂、血尿酸、血同型半胱氨酸情况,进行统计分析,得出结果。结果两组患者在治疗60天后的临床神经功能缺损评分的比较中,均取得疗效。实验组改善脑血栓形成神经功能缺损更为明显,治疗效果更佳;实验组治疗总有效例数为42例,总有效率为93.3%,对照组治疗总有效例数为32例,总有效率为84.2%。两组患者治疗前后UA、Hcy比较,实验组患者治疗后UA、Hcy水平下降,对照组治疗前后UA、Hcy未见明显变化。两组患者治疗前后TG、TC、LDL、HDL比较,实验组患者治疗后TG、TC、LDL水平下降,HDL未见明显变化。对照组治疗前后TG、TC、LDL、HDL未见明显变化。结论脑心通胶囊可降低脑血栓形成患者的TC、TG、LDL的水平,对HDL水平无作用;脑心通胶囊可降低脑血栓形成患者的UA及Hcy水平;脑心通胶囊改善脑血栓形成患者神经功能缺损症状更为明显,治疗效果优于对照组,总有效率优于对照组。

Objective Observe the role of Naoxintong capsules in the treatment of cerebral thrombosis. Study the differences of conventional treatment combined with Naoxintong capsules and general conventional treatment; Observe the effects of Naoxintong capsules on blood fat, blood uric acid and homocysteine.Metbods Select the cerebral thrombosis patients who hospitalized in neurology department and emergency department of the first hospital of Qiqihar. Divide the patients into two groups ： the experimental group and conventional group. There are 45 patients in the conventional treatment group. Then make a clinical research based on NIHSS scale and the conditions of blood fat, blood uric acid and homocysteine before and after the treatment, and at last made a statistical analysis.Results Both groups of the patients have benefited more or less in the grading of neurological function defect after 60 days＂ treatment, and the experimental group produced better result. The total effective rate in the experimental group was 93.3% （42/45）. The total effective rate in the conventional group was 84.2% （32/ 38）. UA and HCY concentration in experimental group decreased significantly, while there was no significant change in conventional group. After the treatment, the levels of TG, TC and LDL in experiment declined. The TG, TC, LDL and HDL levels of the control group didn ＂t changed significantly. Conclusions Naoxintong capsules can reduce the levels of TG, TC and LDL of the patients with cerebral thrombosis, but it has no effects on HDL. Naoxintong capsules can reduce the level of UA and HCY of the patients with cerebral thrombosis. Naoxintong capsules have conspicuous effects on improving the neurological function defect o~ the patients with cerebral thrombosis, the curative effects is better than the control group, and the total effective rate is higher than that of the control group.