HIF-1α、CD44在胃癌组织中的表达及临床意义

Expression and clinical significance of both hypoxia-inducible factor(HIF)-1α and CD44 in gastric cancer

目的探讨缺氧诱导因子1α(hypoxia inducible factor-1α,HIF-1α)、CD44在胃癌组织中的表达及临床意义。方法采用免疫组织化学法检测184例胃癌组织中HIF-1α和CD44的表达,并分析其与患者临床病理特征及预后的关系。结果 HIF-1α、CD44在胃癌组织中的阳性表达率分别为55.4%(102/184)、62.4%(116/184);HIF-1α的表达与肿瘤浸润深度及淋巴结转移密切相关(P<0.05),CD44表达与肿瘤大小、肿瘤浸润深度及淋巴结转移密切相关(P<0.05);相关分析结果显示,CD44和HIF-1α在胃癌组织中的表达呈正相关(r=0.71,P=0.003)。多因素分析显示,HIF-1α阳性表达、CD44阳性表达、淋巴结转移和肿瘤浸润深度为胃癌的独立预后因素(P<0.05)。结论 HIF-1α、CD44在胃癌组织中的表达呈正相关且与胃癌预后密切相关。

Objective To investigate the relationship of expression of both HIF-1α and CD44 with clinicopathological features and outcomes in gastric cancer patients. Methods Tissue from 184 gastric cancer cases who underwent R0 resection were analyzed by immunohistochemistry to examine the expression of HIF-1α and CD44. Potential relationships of expression of HIF-1α and CD44 with clinicopathological features and prognosis were investigated. Results HIF-1α was expressed in 102/184（55.4%）of gastric cancer patients,and CD44 was expressed in 116/184（62.4%）. HIF-1α and CD44 expression correlated with tumor invasion depth and lymphatic metastasis（P〈0.05）,and CD44 expression also correlated with tumor size（P〈0.05）. Spearman rank correlation analysis indicated that HIF-1α expression positively correlated with CD44 expression（r=0.71,P=0.003）. Cox multivariate regression analysis indicated that tumor invasion depth, lymphatic metastasis, HIF-1α and CD44 expression were independent prognostic factors in gastric cancer patients（P〈0.05）.Conclusions HIF-1α expression positively correlated with CD44 expression in gastric cancer patients,and expression of both proteins was related to poor prognosis.