摘要
水通道蛋白4（aquaporin4，AQP4）是水通道蛋白家族成员，在中枢神经系统主要表达于星形胶质细胞终足。大量实验研究显示，AQP4表达对不同类型卒中后脑水肿的发生、发展和消退起着重要作用。此外，AQP4表达还可通过影响血脑屏障完整性以及促进星形胶质细胞迁移、神经再生、神经炎性反应等机制影响脑血管病的发展过程。探讨AQP4在脑内物质跨膜转运和细胞内外环境平衡中的调节机制及其在脑血管病模型中的表达，对于理解临床脑血管病的发生、发展、保护和治疗具有重要的意义。
Aquaporin 4 （AQP4）, a member of the aquaporin family, is mainly expressed in astrocytes end-feet in the central nervous system. A large number of experimental studies have shown that AQP4 expression plays an important role in the occurrence, development, and regression of brain edema after different types of stroke. In addition, the AQP4 expression can affect the development process of cerehrovascular disease through the mechanisms such as affecting the integrity of the blood-brain barrier and promoting astrocyte migration, nerve regeneration, and neuroinflavmnatory response. Investigation of regulation mechanisms of AQP4 in transmembrane transport of substance in brain and intracellular and extracelkdar environmental balance and its expression in model of cerebrovascular disease have an important significance for understanding the occurrence, development, protection, and treatment of clinical cerebrovascular disease.
出处
《国际脑血管病杂志》
2016年第11期1050-1054,共5页
International Journal of Cerebrovascular Diseases
基金
国家自然科学基金（81500998）
