丹参川芎嗪注射液对急性肺挫伤患者临床疗效的研究

Study on the clinical efficacy of Danshen Ligustrazine for injection on acute pulmonary contusion

目的探讨丹参川芎嗪注射液对急性肺挫伤患者白细胞介素-8（IL-8）、血清肿瘤坏死因子-α（TNF-α）的影响。方法将2014年6月~2016年6月在我科接受治疗的60例急性肺挫伤患者按随机数字表法分为对照组29例和治疗组31例,其中对照组予西医常规治疗,治疗组在对照组治疗的基础上辅以丹参川芎嗪注射液静脉滴注,两组疗程均为10 d。比较两组患者平均住院时间、肺部感染率、急性呼吸窘迫综合征（ARDS）发生率等继发性肺损伤指标,并观察两组患者血清IL-8、TNF-α水平变化情况。结果两组临床基线一致,治疗组患者第10天的血清IL-8、TNF-α水平较对照组明显降低,且治疗组的平均住院时间较对照组患者明显减少。结论丹参川芎嗪注射液能显著改善急性肺挫伤患者IL-8、TNF-α水平,促进肺功能恢复,疗效显著,值得临床推广。

Objective To investigate the effects of Danshen Ligustrazine for injection on interleukin-8（IL-8） and serum tumor necrosis factor-α（TNF-α） in the patients with acute lung contusion. Methods 60 patients with acute pulmonary contusion who were given the treatment in our department from June 2014 to June 2016 were divided into the control group（n=29） and the treatment group（n=31） according to the method of random number table. The control group was treated with routine western medicine, and the treatment group was given intravenous drip of Danshen Ligustrazine for injection on the basis of the treamtent in the control group. The course of treatment was 10 days in both groups. The indices of secondary lung injury such as average hospital stay, pulmonary infection rate, and incidence rate of acute respiratory distress syndrome（ARDS） were compared and analyzed between the two groups, and the changes of serum IL-8 and TNF-α levels in the two groups were observed. Results The clinical baseline was consistent in both groups.The levels of serum IL-8 and TNF-α in the treatment group were significantly lower than those in the control group at the tenth day, and the average hospital stay in the treatment group was significantly shorter than that in the control group. Conclusion Danshen Ligustrazine for injection can significantly improve the level of IL-8 and TNF-α in patients with acute lung contusion, and promote the recovery of pulmonary function, which has a significant curative effect and is worthy of clinical promotion.