西双版纳傣族自治州登革病毒2型109例临床特征分析

Clinical characteristics of 109 dengue virus type 2 infected cases in Xishuangbanna

目的探讨西双版纳傣族自治州登革病毒2型（dengue virus type2，DENV-2）感染患者临床特征，为制订当地登革热有效诊疗方案提供依据。方法对2015年西双版纳傣族自治州人民医院收治的109例DENV-2感染患者临床资料和相关生物化学指标进行回顾性分析。结果109例感染DENV-2患者发热比例为100．0％，全身疼痛为97．2％，皮疹为32．1％，出血为11．0％；白细胞计数减少为80．7％，血小板计数减少为89．0％，凝血功能异常为78．9％，肝功能异常为79．8％，心肌酶谱异常为45．9％，。肾功能异常为4．6％。109例患者中重症13例（11．9％），其余为普通登革热患者。结论2015年西双版纳傣族自治州DENV-2流行出现重症病例倾向比例较高，且合并凝血功能异常、肝损伤、心肌损伤多见，提示一旦登革热患者出现上述指征时，医疗部门应引起高度重视，防止重症或死亡发生。

Objective To investigate the clinical characteristics of dengue virus type 2 infected cases in Xishuangbanna, and to provide evidences for effective diagnosis and treatment of local dengue fever. Methods Clinical and laboratory data of 109 dengue virus type 2 infected cases in the People＇s Hospital of Xishuangbanna in 2015 were retrospectively analyzed. Results Among 109 dengue virus type 2 infected cases, the percentages of different symptoms were as follows, fever 100.0%, headache and myalgia 97.2%, skin rash 32.1%, bleeding 11.0%, leucopenia 80.7%, thrombocytopenia 89.0%, coagulopathy 78.9%, hepatic injury 79.8%, myocardial injury 45.9% and renal dysfunction 4.6%. Actually, 13 patients （11.9 % ） were diagnosed with severe dengue fever, and the others were all diagnosed with the common dengue fever. Conclusions The dengue virus type 2 infection in Xishuangbanna, 2015 tends to have higher proportion of severe cases, and coagulopathy, hepatic injury and myocardial injury are frequently seen. Once the dengue fever patients have the above indicators, close attention should be paid so as to prevent severe diseases or even death.