摘要
HIV-1以其高突变率、高重组率和高复制率的生物学特性,使得患者体内的病毒成为复杂的准种,给艾滋病的诊断、治疗和疫苗的研制带来众多难题。高效抗逆转录病毒联合疗法的使用降低了艾滋病患者的病死率,然而在高速复制、高度遗传变异和药物选择压力的作用下,日益严重的耐药问题削弱了其抑制病毒复制的作用,降低了抗病毒治疗的效果。本文综述了HIV-1常见的基因变异特点与耐药之间关系的研究进展,以期对临床制订抗HIV-1药物方案、发展新的抗HIV-1策略带来指导意义。
The biological characteristics of HIV-1 such as high rate of mutation, recombination and replication make the virus become the complicated quasispecies in AIDS, which brings a lot of problems to the diagnosis, treatment even the development of the vaccine. Although the use of highly active antiretroviral therapy（HAART） has greatly reduced the mortality of AIDS, the growing problem of drug resistance has greatly weakened the role of HAART in inhibiting viral replication and the antiviral treatment effect in the result of the high-speed replication, high genetic variation and drug selection pressure. This review focuses on summarizing research progress about the features of gene variation and the relationship between the drug resistance among HIV-1, so as to guide the clinician to make anti-HIV-1 drug programs and new anti-HIV-1 strategies.
出处
《传染病信息》
2016年第6期350-353,共4页
Infectious Disease Information
基金
云南省科技计划项目(2016BC005)
