清肠化湿方联合美沙拉嗪治疗活动期轻中度溃疡性结肠炎的临床疗效

Clinical efficacy of Qingchang Huashi recipe combined with mesalazine in treatment of patients with active ulcerative colitis

目的探讨清肠化湿方(Qingchang Huashi recipe,QHR)联合口服美沙拉嗪治疗活动期轻中度溃疡性结肠炎(ulcerative colitis,UC)的临床疗效.方法 2013-01/2015-01浙江省奉化市中医医院消化科108例UC患者按随机数字表分为观察组和对照组,每组各54例.对照组患者予以美沙拉嗪缓释片口服,观察组患者在对照组治疗的基础上试验组给予QHR口服,2组的疗程均为8 wk.比较治疗后2组患者症状积分、肠镜表现积分、病理积分及临床有效率.同时比较2组患者的血清中的炎症因子水平.结果 (1)观察组患者的症状积分、肠镜表现积分、病理积分较对照组低(均P<0.05);(2)观察组患者的总有效率明显高于对照组(94.4%vs 83.3%,均P<0.05);(3)观察组患者治疗后血清中肿瘤坏死因子-a、白介素(interleukin,IL)-6及IL-17均低于对照组,而血清中的IL-13的水平则明显高于对照组(均P<0.05).结论 QHR联合美沙拉嗪治疗治疗UC能较好的减轻临床症状,改善肠镜及病理表现,同时降低炎症反应,提高临床疗效.

AIM To evaluate the clinical effects of Qingchang Huashi recipe（QHR） combined with mesalazine in treating active ulcerative colitis（UC） patients.METHODS From January 2013 to January 2015,108 patients with active UC treated at our hospital were randomly divided into either a control group or an observation group（n=52 each）.The control group was treated with mesalazine alone,and the observation group was treated with QHR plus mesalazine.The therapeutic course was 8 wk for both groups.Symptom score,colonoscopic results,pathological efficacy,and the remission rate were compared between the two groups.The levels of serum inflammatory factors were also compared.RESULTS At the end of the treatment,the improvement of symptoms,colonoscopic results and pathological efficacy were significantly better in the observation group than in the control group（P〈0.05）.The overall effective rate for the observation group was significantly higher than that of the control group（94.4%us 83.3%,P〈0.05）.Serum levels of tumor necrosis factor-α,interleukin（IL）-6 and IL-17 were significantly lower in the observation group than in the control group,while serum level of IL-13 was significantly higher than that in the control group（P〈0.05）.CONCLUSION QHR combined with mesalazine can improve serum and clinical parameters in active UC patients,and alleviate inflammatory reaction with few adverse reactions.