(S)-N-[(1-甲基-2-吡咯烷基)甲基]三氟甲磺酰胺的合成

Synthesis of( S)-1,1,1-trifluoro-N-[( 1-methylpyrrolidin-2-yl) methyl] methanesulfonamide

目的:以L-脯氨酸为原料合成手性三氟甲磺酰胺有机小分子催化剂。方法:通过酯化、还原、取代等主要反应合成手性小分子催化剂。结果:以小分子L-脯氨酸为原料,通过五个主要合成步骤,以23.7%的总收率合成了三氟甲磺酰胺有机小分子催化剂,产物结构经核磁确认。结论:此法合成三氟甲磺酰胺手性化合物的步骤简单,操作方便,可进行大量合成。

Objective： To synthesize organocatalyst trifluoromethanesulfonamide with the L-proline as the starting material. Methods： Organocatalyst was obtained mainly through reaction,such as esterification,redution,and substitution.Results： With the L-proline as the starting material,the organocatalyst trifluoromethanesulfonamide was got in 23. 7% overall yield through five main synthetic procedures. The structures were determined by NMR. Conclusion： The synthetic route of this chiral trifluoromethanesulfonamide compound is simple,easy to operate,which can be performed at a large scale.