维吾尔族剥脱综合征流行病学特征及血同型半胱氨酸水平研究

Epidemiological characteristics of exfoliation syndrome and levels of homocysteine in Uygur people

目的分析维吾尔族剥脱综合征的流行病学特征,同时探讨血清中同型半胱氨酸(Hcy)水平及与LOXL1基因的甲基化改变联合参与剥脱综合征的发病机制。方法采用ELISA检测病例组与对照组的血Hcy水平,并分析剥脱综合征患者的年龄和性别因素的差异及并发青光眼和白内障的构成比。结果剥脱综合征患病率随年龄增加而增长,差异有统计学意义(χ2=26.9,P<0.05),但男女差异无统计学意义(χ2=1.7,P>0.05),剥脱综合征病例组并发白内障和青光眼的比例较高;Hcy水平病例组(10.42±1.75μmol/L)与对照组(7.28±1.24μmol/L)差异有统计学意义(t=3.49,P<0.05)。结论剥脱综合征是年龄相关性疾病,其发病随年龄增长而增加,LOXL1基因是维吾尔族剥脱综合征患者的危险因素,而血Hcy水平作为剥脱综合征的危险因素,本研究提示Hcy和LOXL1基因的甲基化水平可能在剥脱综合征的发病机制中发挥着一定的作用。

Objective To analyze epidemiological characteristics of exfoliation syndrome and explore serum homocysteine levels as a risk factor of exfoliation syndrome and the methylation changes of LOXL1 gene involved in the pathogenesis of exfoliation syndrome. Methods ELISA was taken to detect levels of Hcy in patients and control subjects, and the differences in age and gender, constituent ratio of exfoliation syndrome and concurrent glaucoma and cataract. Results Exfoliation syndrome prevalence increased with age and growth, with statistical difference（t=26.9, P〈0.05）, but without statistical difference between the male and female（χ2=1.7, P〉0.05）. The proportion of complicated cataract and glaucoma was high in case group. The levels of Hcy concentration were（10.42 ± 1.75） μmol/L in patients with exfoliation syndrome and（7.28 ± 1.24）μmol/L in control subjects, with statistical difference（t=3.49, P〈0.05）. Conclusions Exfoliation syndrome is age-related diseases, the incidence increases with age and growth. LOXL1 is a susceptibility gene of exfoliation syndrome in Uygur people. And high level of homocysteine is a risk factor of exfoliation syndrome. This study suggests that Hcy play a role in the pathogenesis of exfoliation syndrome and the methylation of LOXL1 gene also participates in the process.