淋病奈瑟菌感染引起的淋球菌脑膜炎病例分析

Analysis of a case with gonococcal meningitis caused by Neisseria gonorrhoeae infection

目的对淋病奈瑟菌感染引起的脑膜炎这一罕见病例分析报道,为今后此种病例的鉴别诊断提供帮助。方法通过对病例脑脊液的革兰氏染色镜检、乳胶凝集及API生化鉴定,确定该病例感染的病原体。结果脑脊液细菌培养,24 h后肉眼可见培养基上有圆形、凸起、灰白色、半透明、直径0.5-1.0 mm的光滑型菌落;生化检测确定为青霉素酶阴性的淋病奈瑟菌,确诊为淋球菌脑膜炎。结论淋病奈瑟菌不仅通过性接触直接感染,只要环境条件达到病原菌生长的要求,也可以通过非性接触进行传播,日常生活中密切接触引起的交叉感染更具伤害性和隐蔽性。

Objective To analyze and report a rare case of gonococcal meningitis caused by Neisseria gonorrhoeae, for a reference to the differential diagnosis. Methods Pathogen of the infected case was confirmed by cerebrospinal fluid gram staining, microscopy, latex agglutination and API biochemical detection. Results After bacterial culture of cerebrospinal fluid for 24 hrs, smooth colony of 0.5 to 1.0 mm in diameter displayed pale and translucent circle and bump. Biochemical test confirmed penicillin enzyme negative bacteria Neisseria gonorrhea, and the case was diagnosed to be Neisseria gonorrhoeae meningitis. Conclusions Neisseria gonorrhoeae infects not only through direct sexual contact, as long as the environmental conditions of growth of the pathogen is suitable, also can be spread through no-sexual contact, and close contact in daily life is more noxious and concealment.