中年H型高血压患者颈动脉内中膜厚度与Hcy、Cyst-C、UA、Lp(a)的相关性研究

Study on the correlation of carotid IMT with Hcy,Cyst-C,UA,and Lp(a) in middle-aged patients with H-type hypertension

目的:探讨中年H型高血压患者颈动脉内中膜厚度(cIMT)与同型半胱氨酸(Hcy)、胱抑素C(Cyst-C)、尿酸(UA)、脂蛋白(a)[Lp(a)]的相关性。方法:选取2015年7月~2016年7月收治的中年H型高血压患者120例为研究对象,采用彩色多普勒超声诊断仪进行二维超声检查,依据颈动脉粥样硬化(AS)诊断标准分为正常组、增厚组、斑块组各40例。采用全自动生化分析仪测定各组血浆Hcy、Cyst-C、UA、肌酐(Scr)、尿素氮(Bun)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),乳胶浊度法测定脂蛋白(a)[Lp(a)]。结果:Hcy、Cyst-C、Lp(a)、UA水平随cIMT增厚而升高,HDL-C浓度随cIMT增厚而降低。结论:中年H型高血压患者血清Hcy、Cyst-C、UA、Lp(a)水平与cIMT呈正相关,是导致颈AS独立危险因素,可作为判断AS发生发展的早期指标。

Objective：To explore the correlation of carotid IMT（cIMT）with Hcy,Cyst-C,UA,and Lp（a）in middleaged patients with H-type hypertension.Methods：A total of 120 middle-aged patients with H-type hypertension who were admitted in our hospital from July,2015 to July,2016 were included in the study.The color Doppler ultrasound diagnostic apparatus was used for the two-dimensional ultrasound examination.The patients were divided into the normal group,thickening group,and plaque group with 40 cases in each group according to the atherosclerosis（AS）.The full automatic biochemical analyzer was used to detect the plasma Hcy,Cyst-C,UA,Scr,Bun,TC,TG,LDL-C,and HDL-C.Emulsion turbidity method was used to detect Lp（a）.Results：With the thickening of cIMT,Hcy,Cyst-C,Lp（a）,and UA levels were elevated,while HDL-C level was reduced.Conclusions：The serum Hcy,Cyst-C,UA,and Lp（a）levels in middle-aged patients with H-type hypertension are positively correlated with cIMT,are the independent risk factors for developing AS,and can be served as the early indicators to estimate the occurrence and development of AS.