甲状腺功能亢进患者骨密度、骨代谢指标及细胞因子的变化研究

Changes of bone mineral density,bone metabolism indices and cell factors in patients with hyperthyroidism

目的:探讨甲状腺功能亢进患者骨密度、骨代谢指标及细胞因子的水平变化。方法:选取2015年6月~2016年6月四川省德阳市人民医院收治的甲状腺功能亢进患者116例作为观察组对象,另选取同期于我院体检的健康者120例作为对照组对象,检测所有对象的甲状腺功能指标(TT3、TT4、FT3、FT4、TSH)、骨密度(BMD)、骨代谢指标(PTH、BGP、PINP)以及细胞因子(IL-2、IL-6),并进行比较。结果:观察组的TT3、TT4、FT3、FT4均高于对照组,TSH低于对照组(P<0.05);观察组BMD、PTH水平显著低于对照组(P<0.05),观察组BGP、PINP水平显著高于对照组(P<0.05);观察组IL-2水平显著低于对照组(P<0.05),观察组IL-6水平显著高于对照组(P<0.05)。结论:甲状腺功能亢进患者骨密度降低、骨代谢活跃,细胞因子IL-2、IL-6也有明显变化,临床工作中应加强上述指标的检测,以便及时采取措施,防治骨质疏松等并发症。

Objective：To observe the changes of bone mineral density,bone metabolism indices and cell factor in patients with hyperthyroidism Methods：A total of 116 cases of hyperthyroidism patients from June 2015 to June 2016 in our hospital were selected as the objects of observation group.Then,120 cases of healthy people were selected as the objects of control group.Thyroid function indexes（TT3,TT4,FT3,FT4,TSH）,bone mineral density（BMD）,bone metabolism indexes（PTH,BGP,PINP）and cell factors（IL-2,IL-6）in both groups were detected and compared.Results：TT3,TT4,FT3,FT4 in the observation group were significantly higher than that in control group（P〈0.05）.TSH in the observation group was significantly lower than that in observation group（P〈0.05）.BMD,PTH in observation group were significantly lower than that in control group（P〈0.05）.BGP,PINP in observation group were significantly higher than that in control group（P〈0.05）.IL-2 in observation group was significantly lower than that in control group.IL-6 in observation group was significantly higher than that in control group（P〈0.05）.Conclusions：Bone mineral density in patients with hyperthyroidism decrease and bone metabolism in patients with hyperthyroidism is active.The significant changes of IL-2and IL-6 also can be seen.In the clinical,we should enhance the detection of these indexes,so as to take measures to prevent and cure the complications such as osteoporosis.