仙灵骨葆辅助外科治疗老年妇女Colles骨折的愈合时间、钙磷含量及骨代谢的评估

Healing time,calcium and phosphorus contents as well as bone metabolism evaluation after Xianling Gubao-assisted surgical treatment of Colles fracture in elderly women

目的:研究仙灵骨葆辅助外科治疗对老年妇女Colles骨折术后愈合、钙磷含量及骨代谢的影响。方法:选择2013年6月~2015年12月期间在武汉科技大学附属天佑医院就诊的96例老年女性Colles骨折患者,随机分为两组,观察组患者接受仙灵骨葆胶囊联合手法复位石膏外固定治疗、对照组患者只接受复位外固定治疗。治疗后随访骨折愈合时间,治疗后3个月时采集血清并测定钙磷代谢指标、骨代谢指标的含量。结果:观察组患者的骨折愈合时间显著短于对照组;治疗后1个月、3个月时,两组患者血清中Ca、P、ALP、IGF-1、PDGF、BGP、PICP的含量均显著高于治疗前,CTX-1、tPINP、TRACP-5b的含量均显著低于治疗前(P<0.05);观察组患者治疗后血清中Ca、P、ALP、IGF-1、PDGF、BGP、PICP的含量均显著高于对照组,CTX-1、tPINP、TRACP-5b的含量均显著低于对照组(P<0.05)。结论:仙灵骨葆胶囊辅助治疗能够促进老年女性Colles骨折的愈合,同时改善钙磷代谢、促进骨形成过程并抑制骨吸收过程。

Objective：To study the effect of Xianling Gubao-assisted surgical treatment on postoperative healing,calcium and phosphorus contents as well as bone metabolism in elderly women with Colles fracture.Methods：A total of 96 elderly female patients with Colles fracture treated in our hospital between June 2013 and December 2015 were selected and randomly divided into two groups,the observation group of patients received Xianling Gubao capsule combined with manual reduction and plaster external fixation therapy,and control group of patients only received reduction and external fixation therapy.The fracture healing time was followed up after treatment,and 3 months after treatment,serum was collected to determine the content of calcium-phosphorus metabolism indexes and bone metabolism indexes.Results：The fracture healing time of observation group was significantly shorter than that of control group;1 month and 3 months after treatment,serum Ca,P,ALP,IGF-1,PDGF,BGP and PICP levels of both groups were significantly higher than those before treatment while CTX-1,tPINP and TRACP-5blevels were significantly lower than those before treatment（P〈0.05）;serum Ca,P,ALP,IGF-1,PDGF,BGP and PICP levels of observation group after treatment were significantly higher than those of control group while CTX-1,tPINP and TRACP-5blevels were significantly lower than those of control group（P〈0.05）.Conclusions：Adjuvant Xianling Gubao capsule therapy can promote the Colles fracture healing in elderly women,also improve calcium-phosphorus metabolism,promote bone formation and inhibit bone resorption.