非酒精性脂肪性肝病相关肝癌发病机制的研究进展

Research advances in the pathogenesis of non-alcoholic fatty liver disease-associated liver cancer

非酒精性脂肪性肝病（NAFLD）是临床上最常见的慢性肝脏疾病之一，可从单纯性脂肪肝进展为非酒精性脂肪性肝炎、肝纤维化和肝硬化，最终可发展为肝细胞肝癌（HCC）。尽管研究表明，许多细胞信号通路、基因及细胞因子等参与NAFLD相关的HCC的发生发展，但是其发病的具体分子机制尚不清楚。现结合国内外近年的文献报道，对NAFLD相关的HCC的流行病学及发病机制做一综述。

Nonalcoholic fatty fiver disease （NAFLD） is one of the most common causes of chronic liver disease in clinical practice. It develops from simple fatty liver, nonalcoholic fatty hepatitis to liver fibrosis which may develop liver cirrhosis and result in hepatocellular careinoma（HCC） eventually. Although studies show that many cell signaling pathways, genes and cell factors are involved in the progression and development of NAFLD related HCC, the exact mechanism underling the pathogenesis of NAFLD-HCC remains poorly understand. Here in this review, we give a summary of the recent findings at home and abroad that describe the epidemiology and pathogenesis of NAFLD associated HCC.