哺乳动物前庭毛细胞损伤与再生的研究进展

Research advances in the damage and regeneration of mammalian vestibular hair cells

眩晕是临床常见症状之一，对患者的生活质量有明显影响。前庭毛细胞损伤所引起的前庭功能障碍是眩晕发生的重要原因，目前尚无有效方法使损伤后的哺乳动物前庭毛细胞完全再生。研究前庭毛细胞的损伤机制，从而探讨促进其再生与功能恢复的方法，对于眩晕防治意义重大。本文就哺乳动物前庭毛细胞损伤与再生机制，以及潜在的再生策略综述如下。

Vertigo is a common symptom in the clinic and impacts life quality of patients. It is closely related to the damage of vestibular hair cells. So far, there is no available approach which can facilitate abundant regeneration of mammalian vestibular hair cells, so as to recover the impaired vestibular function. Illuminating the mechanisms underlying vestibular hair cell damage and developing potential therapeutic strategies for vestibular hair cell regeneration are of great significance for the prevention and treatment of vertigo. In this study, we summarized research advances in the damage and regeneration of mammalian vestibular hair cells.