FoxM1与BCRP在非特殊型浸润性乳腺癌中的表达及其预后意义

Expression of FoxM1 and BCRP in invasive breast carcinoma of no special type and its prognosis ;significance

目的：探讨叉头蛋白转录因子M1（FoxM1）、乳腺癌耐药蛋白（BCRP）在非特殊型浸润性乳腺癌（ IBC-NST）中的表达及其预后意义。方法选取本院2009至2010年78例IBC-NST病例手术切除标本，免疫组织化学检测FoxM1和BCRP在IBC-NST中的表达情况，采用卡方检验分析其表达与患者临床病理特征及预后的关系。结果 FoxM1在IBC-NST中阳性率为71.8％（56／78），其表达与肿瘤直径、TNM分期、雌激素受体（ ER ）、孕激素受体（ PR ）、HER2相关，差异有统计学意义（ P ＜0.05）；BCRP在IBC-NST中阳性率为53.8％（42／78），其表达与年龄、肿瘤直径、淋巴结转移、ER、HER2相关，差异有统计学意义（P＜0.05）。 Kaplan-Meier生存分析结果显示，患者生存时间与肿瘤直径、TNM分期、淋巴结转移、FoxM1、BCRP、ER、PR和HER2有关，差异有统计学意义（ P＜0.05）；多因素Cox回归结果显示，TNM分期、FoxM1、BCRP、HER2是影响患者生存时间的主要因素。结论对于IBC-NST患者，FoxM1的表达与肿瘤直径、TNM分期、ER、PR、HER2有关；BCRP的表达与年龄、肿瘤直径、淋巴结转移、ER、HER2有关。 FoxM1与BCRP均为患者预后影响因素。

Objective To investigate the relationship between expression of FoxM 1 and BCRP in invasive breast carcinoma of no special type （ IBC-NST） tissues and the clinical pathological characteristics and prognosis of the patients .Methods Seventy-eight cases of IBC-NST with excision were included .The expression of FoxM1 and BCRP was assessed by immunohistochemistry and its relationship with the clinical pathological characteristics and prognosis was evaluated .Results FoxM1 was expressed in 71.8%（56/78） of IBC-NST, and the expression was related to tumor diameter , TNM staging, ER, PR and HER2.BCRP was expressed in 53.8% （ 42/78 ） of IBC-NST, and the expression was related to age , tumor diameter , lymph node metastasis , ER and HER2.Kaplan-Meier survival analysis showed the survival time was related to tumor diameter, TNM staging, lymph node metastasis and the expression of FoxM 1, BCRP, ER, PR and HER2.Cox multivariate analysis showed that TNM staging , FoxM1, BCRP, HER2 were determinants of patient survival time.Conclusions The expression of FoxM 1 is associated with tumor diameter , TNM staging, ER, PR and HER2 while BCRP is associated with age, tumor diameter, lymph node metastasis, ER and HER2.Both FoxM1 and BCRP have prognostic significance in IBC-NST patients.