山东省交通医院门诊抗菌药物超说明书用药情况调查

Off -label use of antibacterial agents in Traffic Hospital of Shandong Province in 2016：a cross sectional study

目的：了解山东省交通医院门诊抗菌药物超说明书用药情况，对其用药现状进行调查与分析。方法随机抽取山东省交通医院2016年1～4月门诊抗菌药物处方，根据药品说明书判断是否属于超说明书用药。结果共抽取门诊抗菌药物处方1264张，其中涉及抗菌药物58种。超说明书用药主要包括超适应人群（23．42％）、适应证（4．15％）、剂量（6．31％）、给药频次（62．95％）、给药途径（3．15％）。结论门诊抗菌药物超说明书用药现象较为普遍，应对超说明书用药进行规范管理。

Objective To determine the off -label use of antibacterial agents,we investigated and analyzed the current status about off -label use of antibacterial agents.Methods The random sampling was conducted to select the outpatient prescription including antibacterial agents from January to April in 2016.According to drug instructions,the off -label drug use of prescription was analyzed.Results 1 264 prescriptions involving 58 kinds of drugs were analyzed.The main categories of off -label drug use were no pediatric and elderly information（23.42%）, indication（4.1 5%）,dosage （6.31 %）,dosage range （62.95%）and administration route （3.1 5%）.Conclusion The off -label use of antibacterial agents is common in our hospital.It＇s in need to regulate off -label drug use.