UV/H_2O_2工艺降解典型消炎药布洛芬影响因素和降解机理

Influence factors and degradation mechanism of UV/H_2O_2 process for degradation of typical anti-inflammatory drug ibuprofen

布洛芬是一种典型药物和个人护理用品(PPCPs),大量生产和广泛使用给环境带来了一定危害。基于响应面方法,采用UV/H_2O_2工艺降解布洛芬(IB),对降解过程中的影响因素(光强、H_2O_2投加量、初始IB浓度)进行了探讨,构建响应面模型。优化的最佳反应条件为:H_2O_2投加量0.10 mol·L^(-1)、初始IB浓度5.00 mg·L^(-1)、UV光强1 400μW·cm^(-2),预测和实验IB以及反应动力学速率常数接近,说明响应面模型能够有效描述UV/H_2O_2降解反应过程。同时用离子阱质谱仪鉴定出IB羟基加成物、4-乙基苯酚、对异丁基苯甲酸等降解中间产物,其中IB羟基加成物的细胞毒性大于IB本身,最后提出降解机理。本研究为UV/H_2O_2工艺降解典型消炎药类污染物提供技术参考。

Ibuprofen,a typical pharmaceutical and personal care product（ PPCP）,has damaged the environment due to its mass production and extensive use. In this study,a UV / H_2O_2 treatment process for removing ibuprofen（ IB） was developed based on the response surface method. The parameters of the degradation process,including the light intensity,H_2O_2 dosage and initial concentration,were used to construct the response surface model. The optimized conditions were as follows： H_2O_2 dosage of 0. 10 mol · L^-1,initial IB concentration of5. 00 mg·L^-1,and UV light intensity of 1 400 μW·cm^（-2）. The predicted IB degradation rate was reasonable close to the experimental value,which indicates that the response surface model can effectively describe the UV /H_2O_2 degradation process. Ion trap mass spectrometry was used to identify several degradation intermediates,including hydroxylated ibuprofen,4-ethyl phenol,and iso-butyl benzoic acid. The cytotoxicity of hydroxylated ibuprofen is stronger than that of IB itself. Finally,a degradation mechanism was also proposed. This study provides technical references for the degradation of typical anti-inflammatory drug contaminants by UV / H_2O_2 treatment.