支气管动脉灌注化疗联合榄香烯对晚期肺癌患者病灶恶性分子及全身免疫应答的影响

Effect of bronchial arterial infusion chemotherapy combined with elemene on the malignant lesion molecules and systemic immune response in patients with advanced lung cancer

目的:研究支气管动脉灌注化疗联合榄香烯对晚期肺癌患者病灶恶性分子及全身免疫应答的影响。方法:选择2013年4月~2016年3月期间在我院确诊为晚期肺癌的78例患者作为研究对象,随机分为接受支气管动脉灌注化疗联合榄香烯治疗的观察组以及接受支气管动脉灌注化疗的对照组。治疗后4周时,采集肿瘤病灶并测定增殖和侵袭分子的表达量,采集血清并测定免疫细胞相关细胞因子的含量。结果:治疗后4周时,观察组肿瘤病灶中TCF3、Livin、Bcl-2、HOXB7、PTTG1、Vimentin、E-cadherin、Rap2a、β-catenin的蛋白表达量均显著低于对照组;观察组血清中γ干扰素(IFN-γ)的含量显著高于对照组,白介素(IL)-4、IL-9、IL-10、转化生长因子(TGF)-β的含量显著低于对照组。结论:支气管动脉灌注化疗联合榄香烯对晚期肺癌患者病灶中增殖和侵袭分子的表达具有抑制作用、对全身抗肿瘤免疫应答具有改善作用。

Objective：To study the effect of bronchial arterial infusion chemotherapy combined with elemene on the malignant lesion molecules and systemic immune response in patients with advanced lung cancer.Methods：A total of 78 patients diagnosed with advanced lung cancer in our hospital between April 2013 and March 2016 were selected as research subjects and randomly divided into observation group who accepted bronchial arterial infusion chemotherapy combined with elemene therapy and control group who accepted bronchial arterial infusion chemotherapy.After 4weeks of treatment,tumor lesions were collected to determine the expression of proliferation and invasion molecule,and serum was collected to determine the levels of immune cell-related cytokines.Results：After 4weeks of treatment,TCF3,Livin,Bcl-2,HOXB7,PTTG1,Vimentin,E-cadherin,Rap2aandβ-catenin protein expression in tumor lesions of observation group were significantly lower than those of control group;serum IFN-γlevel of observation group was significantly higher than that of control group while IL-4,IL-9,IL-10and TGF-βlevels were significantly lower than those of control group.Conclusions：Bronchial arterial infusion chemotherapy combined with elemene can inhibit the expression of proliferation and invasion of molecules in tumor lesions and improve the systemic anti-tumor immune response in patients with advanced lung cancer.