新生儿败血症外周血中PCT、SAA、CD64含量与炎症反应程度及脏器功能的相关性

Correlation of PCT,SAA and CD64 levels in peripheral blood with the inflammatory response and viscera function in neonate with sepsis

目的:研究新生儿败血症外周血中降钙素原(PCT)、淀粉酶A蛋白(SAA)、CD64含量与炎症反应程度及脏器功能的相关性。方法:选择2014年3月~2016年3月期间在我院确诊为败血症的35例新生儿作为研究的败血症组,同期在我院出生的60例健康新生儿作为对照组,采集外周血标本并测定PCT、SAA、CD64以及炎性因子、心肌损伤标志分子、肝脏损伤标志分子的含量。结果:败血症组患儿外周血中PCT、SAA、CD64、sTREM-1、肿瘤坏死因子(TNF)-α、白介素(IL)-6、IL-8、心肌肌钙蛋白I(cTnI)、心肌肌钙蛋白T(cTnT)、心脏型脂肪酸结合蛋白(H-FABP)、肌酸激酶同工酶(CK-MB)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、谷酰转肽酶(GGT)、总胆红素(TBIL)、直接胆红素(DBIL)的含量均显著高于对照组;外周血中PCT、SAA、CD64的含量与sTREM-1、TNF-α、IL-6、IL-8、cTnI、cTnT、H-FABP、CK-MB、AST、ALT、GGT、TBIL、DBIL的含量呈正相关关系。结论:新生儿败血症外周血中PCT、SAA、CD64含量显著升高且与炎症反应程度、心肌损伤及肝脏损伤程度有关。

Objective：To study the correlation of PCT,SAA and CD64 levels in peripheral blood with the inflammatory response and viscera function in neonate with sepsis.Methods：A total of 35 neonates diagnosed with sepsis in our hospital between March 2014 and March 2016 were selected as the sepsis group of the study,60 healthy neonates born in our hospital during the same period were selected as the control group,peripheral blood samples were collected to determine the levels of PCT,SAA,CD64 as well as inflammatory factors,myocardial injury marker molecules and liver injury marker molecules.Results：PCT,SAA,CD64,sTREM-1,TNF-α,IL-6,IL-8,cTnI,cTnT,H-FABP,CK-MB,AST,ALT,GGT,TBIL and DBIL levels in peripheral blood of sepsis group were significantly higher than those of control group;PCT,SAA and CD64 levels in peripheral blood were positively correlated with sTREM-1,TNF-α,IL-6,IL-8,cTnI,cTnT,H-FABP,CK-MB,AST,ALT,GGT,TBIL and DBIL levels.Conclusions：PCT,SAA and CD64 levels in peripheral blood of neonatal sepsis significantly increase and are associated with the degree of inflammation,myocardial injury and liver injury.