慢性阻塞性肺疾病急性加重期患者TNF-α、sTNF-R55、sTNF-R75水平变化表达

The Expression of TNF-α,sTNF-R55 and sTNF-75 for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者的肿瘤坏死因子(TNF-α)和可溶性肿瘤坏死因子s TNF-R55、s TNF-75的水平变化。方法:选择2015年8月-2016年8月在本院就诊的120例AECOPD患者作为观察组,并选择同时期的120健康志愿者作为对照组,对比两组患者在入院第1、7天的TNF-α和s TNF-R55、s TNF-75水平三项指标以及肺功能。结果:观察组治疗后其肺功能有了明显改善,但与对照组相比差异有统计学意义(P<0.05)。观察组治疗前后血浆TNF-α和s TNF-R55、s TNF-75水平相比于对照组有明显的提高,差异均有统计学意义(P<0.05);此外在对照组中吸烟者的TNF-α也是要明显高于不吸烟者(P<0.05)。观察组在第7天血浆中的TNF-α水平要低于入院第1天(P<0.05),而s TNF-R55、s TNF-75水平较前有一定程度上升,但差异均无统计学意义(P>0.05)。结论:对于AECOPD患者而言,其血中的TNF-α和s TNF-R55、s TNF-75水平相比于正常人群要明显高出,通过积极正规的治疗后,TNF-α水平有明显下降,但是抗炎介质水平上升程度有限。

Objective：To observe the clinical expression of TNF-α,s TNF-R55 and s TNF-75 for acute exacerbation of chronic obstructive pulmonary disease（AECOPD） patients.Method：A total of 120 AECOPDpatients treated in our hospital from August 2015 to August 2016 were selected as the observation group.120 healthy volunteers were selected as the control group.After 1,7 d of admission,the levels of TNF-α,s TNF-R55 and s TNF-75 and the pulmonary function of two groups were compared.Result：After treatment,the pulmonary function for AECOPD patients was greatly improved,however the pulmonary function of the observation group and the control group was significantly different（P〈0.05）.Before and after treatment,the levels of TNF-α,s TNF-R55 and s TNF-75 of the observation group were significantly higher than those of the control group（P〈0.05）.In the control group,the level of TNF-α of smoking patients was higher than that of non-smoking patients（P〈0.05）.In the observation group,the level of TNF-α after 7 d of admission was lower than that of after 1 d of admission（P〈0.05）.After treatment,the levels of s TNF-R55 and s TNF-75 were slightly better than those of before treatment,but there were no statistical significance（P〉0.05）.Conclusion：AECOPD patients,the levels of TNF-α,s TNF-R55 and s TNF-75 are higher than those of healthy volunteers.Through the positive and regular treatment,the level of TNF-α is greatly reduced,however,the anti-inflammatory mediators are increased in a lower way.