硫酸镁联合硝苯地平治疗妊娠期高血压疾病产后降压治疗效果分析

Effect of Magnesium Sulfate Combined with Nifedipine in the Treatment of Postpartum Antihypertensive in Hypertensive Disorders Complicating Pregnancy

目的:探讨硫酸镁联合硝苯地平治疗妊娠期高血压疾病产后降压治疗效果。方法:选取2014年9月-2016年6月本院确诊治疗的妊娠期高血压疾病患者120例,依据随机数字表法分为硫酸镁组和硫酸地平组,每组60例。硫酸镁组患者给予硫酸镁静脉滴注治疗,硝苯地平组患者在此基础上给予30 mg硝苯地平口服治疗,统计分析两组患者治疗前后收缩压、舒张压、子宫动脉的收缩期最大血流速度与舒张末期血流速度之比(S/D)、搏动指数(PI)、阻力指数(RI)水平、产后出血、治疗期间不良反应发生情况。结果:硝苯地平组治疗后收缩压、舒张压水平均明显低于硫酸镁组,前者血压达标率明显高于后者,差异均有统计学意义(P<0.05);硝苯地平组治疗后子宫动脉的S/D,PI、RI水平和产后出血发生率均明显低于硫酸镁组,差异均有统计学意义(P<0.05);硫酸镁组和硫酸地平组不良反应发生率基本相同,差异无统计学意义(P>0.05)。结论:硫酸镁联合硝苯地平治疗可有效提高妊娠期高血压疾病患者产后降压效果,可有效改善患者子宫动脉的血流动力学,有利于避免产后出血的发生,且具有良好的安全性,值得临床作进一步推广。

Objective：To discuss the curative effect of Magnesium Sulfate combined with Nifedipine in the Treatment of Postpartum Antihypertensive in hypertensive disorders complicating pregnancy.Method：A total of 120 patients with hypertensive disorders complicating pregnancy were selected from September 2014 to June 2016 in our hospital.According to the random distribution,all patients were divided into Magnesium Sulfate group and Nifedipine group,60 cases in eachgroup,Magnesium Sulfate group was treated with Magnesium Sulfate intravenous drip,on the base of Magnesium Sulfate group,Nifedipine group was given Nifedipine 30 mg,before and after treatment systolic blood pressure,diastolic pressure,uterine artery systolic blood flow velocity and the largest enddiastolic blood flow velocity ratio（S/D）,pulse index（PI）,resistance index（RI） levels,postpartum hemorrhage,treatment,adverse reactions occurred of two groups were compared.Result：After treatment systolic pressure,diastolic blood of Nifedipine group were lower than those of Magnesium Sulfate group,the former blood pressure success rate was significantly higher than that of the latter,there were statistically difference（P〈0.05）.After treatment uterine artery S/D,PI,RI levels and the incidence of postpartum hemorrhage of Nifedipine group were lower than those of Magnesium Sulfate group,there were statistically significant（P〈0.05）.The incidence adverse reactions of Magnesium Sulfate group and Nifedipine group were basically the same,there was no significant difference（P〉0.05）.Conclusion：Magnesium Sulfate combined with Nifedipine therapy can effectively improve postpartum antihypertensive curative effect of patients with hypertensive disorders complicating pregnancy,it can effectively improve the uterine artery hemodynamics,it is help to avoid the occurrence of postpartum hemorrhage,and it has a good security,it＇s worth of further clinical promotion.