肺结核患者T细胞及相关细胞因子的动态变化及临床价值

Analysis of the dynamic change and clinical application values of T cell and correlative cytokines for the patients with pulmonary tuberculosis

目的探讨肺结核患者T细胞及相关细胞因子的动态变化及临床价值。方法比较100例肺结核患者(实验组)治疗前后及100例健康志愿者(对照组)T细胞亚群及相关细胞因子水平,进一步比较实验组治疗后不同病灶吸收情况患者T细胞亚群及相关细胞因子水平。结果实验组患者治疗前CD3^+、CD4^+、CD4^+/CD8^+、干扰素-γ(IFN-γ)水平均明显低于对照组,肿瘤坏死因子-α(TNF-α)、白介素(IL)-10水平均明显高于对照组,差异具有显著性(P<0.05);实验组患者治疗后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、IFN-γ、TNF-α、IL-2、IL-10水平与对照组比较,差异无统计学意义(P>0.05);实验组治疗后病灶明显吸收者CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、IFN-γ、TNF-α、IL-2、IL-10水平与对照组比较,差异无统计学意义(P>0.05);实验组治疗后病灶吸收不良者CD4^+、CD4^+/CD8^+、IFN-γ水平明显低于病灶明显吸收者和对照组,差异具有显著性(P<0.05)。结论 T细胞及相关细胞因子对肺结核的诊断和治疗效果评估有指示作用,临床应用价值较高。

Objective To explore the dynamic change and clinical application values of T cell and correlative cytokines for the patients with pulmonary tuberculosis.Methods One hundredcases of patients with pulmonary tuberculosis were selected as the experiment group,100 cases of healthy volunteers as the control group.The T cell and correlative cytokines were compared,and the levels of lesions absorption were analyzed.Results The levels of CD3^＋,CD4^＋,CD4^＋/ CD8^＋,IFN-γ in the experiment group were lower than those in the control group before treatment（ P〈0.05）.The levels of TNF-α,IL-10 for the experiment group were higher than those of the control group before treatment（ P〈0.05）.There has no significant difference of the levels of CD3^＋,CD4^＋,CD8^＋,CD4^＋/ CD8^＋,IFN-γ,TNF-α,IL-2,IL-10 for the experiment group（ P〈0.05）.There has no significant difference on the levels of CD3^＋,CD4^＋,CD8^＋,CD4^＋/ CD8^＋,IFN-γ,TNF-α,IL-2,IL-10 for the two groups（ P〈0.05）.The levels of CD4^＋,CD4^＋/ CD8^＋,IFN-γ for the experiment group of lesions malabsorption were lower than lesions obvious absorption and the control group（ P〈0.05）.Conclusion The levels of T cell and correlative cytokines has indication for the patients with pulmonary tuberculosis.Therefore,it has high values of clinical application.