冠心病合并肺部感染患者Ghrelin/obestatin变化及意义

The change and significance of Ghrelin/obestatin in patients with coronary heart disease complicated with pulmonar infections

目的探讨冠心病合并肺部感染患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)变化及临床意义。方法收集冠心病患者120例作为研究对象,根据是否合并肺部感染分为冠心病肺部感染组(n=52)和单纯冠心病组(n=68),选择同期健康志愿者50例作为对照组。采用ELISA法测定血清Ghrelin、obestatin水平。根据冠脉造影结果采用Gensini积分评估冠脉病变程度,观察Ghrelin/obestatin与Gensini积分的相关性。结果冠心病肺部感染组、单纯冠心病组患者的Ghrelin/obestatin显著低于对照组,差异均有统计学意义(P<0.05)。冠心病肺部感染组患者的Gensini积分明显高于单纯冠心病组,差异有统计学意义(P<0.05)。冠心病合并肺部感染组患者的Ghrelin/obestatin与Gensini积分呈负相关(r=-0.66,P<0.01)。结论冠心病合并肺部感染患者的Ghrelin/obestatin与冠状动脉病变程度密切相关。Ghrelin/obestatin在预测冠心病合并肺部感染中有一定的辅助参考价值。

Objective To investigate the change and clinical significance of Ghrelin/obestatin in patients with coronary heart disease complicated with pulmonar infections. Methods 120 cases of coronary heart disease patients were selected as research subjects,according to whether complicated with pulmonar infections they were divided into coronary heart disease complicated with pulmonar infections group（ n = 52） and simple coronary heart disease group（ n = 68）. 50 cases of healthy people at the same period were selected as the control group. Serum Ghrelin and obestatin levels were measured by ELISA. Gensini score was used to evaluate the extent of coronary lesions according to the results of coronary angiography. The correlation between Ghrelin / obestatin and Gensini integral was observed. Results The Ghrelin / obestatin ratios in coronary heart disease complicated with pulmonar infections group and simple coronary heart disease group were significantly lower than those in the control group,the difference were statistically significant（ P〈0. 05）. The Gensini score of coronary heart disease complicated with pulmonar infections group was significantly higher than that of the simple coronary heart disease group,the difference were statistically significant（ P〈0. 05）. The Ghrelin / obestatin ratio of patients with coronary heart disease complicated with pulmonar infections was negatively correlated with Gensini score（ r =- 0. 66,P〈0. 01）. Conclusion Ghrelin / obestatin ratio is closely related to the degree of coronary artery disease in patients with coronary heart disease complicated with pulmonar infections. Ghrelin / obestatin ratio has a supplementary reference value in predicting coronary heart disease combined with pulmonar infections.