咪唑立宾治疗儿童频复发型原发肾病综合征45例疗效观察

Effect of mizoribine in the treatment of children with frequently relapsing primary nephrotic syndrome

目的观察咪唑立宾(MZR)对儿童频复发型原发肾病综合征的疗效。方法将2013年4月至2015年1月中南大学湘雅二医院儿童医学中心儿童肾脏专科的住院或门诊登记完整的儿童频复发型原发肾病综合征45例纳入研究,观察对照组(雷公藤+泼尼松)24例和治疗组(咪唑立宾+泼尼松)21例1年内患儿复发次数、波尼松用量、肾小球滤过率、血清白蛋白、尿蛋白、尿酸等指标的变化。结果予以MZR治疗后,治疗组患儿复发次数减少,泼尼松有效用量下降、肾小球滤过率无下降、血清白蛋白水平上升、尿蛋白减少、尿酸水平无明显变化。结论 MRZ是治疗儿童频复发型原发肾病综合征的有效药物。

Objective To observe the effect of mizoribine （MZR） in the treatment of children with frequently relapsing primary nephrotic syndrome. Methods Totally 21 children with frequently relapsing nephrotic syndrome were treated with mizoribine, and another 24 children were included as the control group. Observe the changes of relapse number, dosage of prednisone, glomerular filtration rate, serum albumin, urine protein, uric acid and other indicators. Results After the treatment with mizoribine, the recurrence rate and the effective dosage of prednisone decreased, serum albumin level rose, and primary urinary protein decreased, but there were no significant changes in glomerular filtration rate and uric acid level. Conclusion The mizoribine is effective in treatment of children with frequently relapsing primery nephrotic syndrome .