肺癌并静脉血栓栓塞症的危险因素分析

Analysis of risk factors of venous thromboembolism in lung cancer patients

目的总结我院38例肺癌合并静脉血栓患者的临床资料，探讨其发生的危险因素。方法对2010年4月至2015年7月本院38例肺癌合并静脉血栓患者（血栓组）与同期76例不存在静脉血栓的肺癌患者（非血栓组）的临床资料进行回顾性病例-对照分析。单因素分析后，对有可能有意义的因素进行多因素Logistic回归分析，查找肺癌合并静脉血栓的危险因素。结果单因素分析显示腺癌、ⅢB-Ⅳ期、D二聚体增高、中心静脉置管、CEA增高是发生静脉血栓的危险因素（P〈0．05）。多因素回归分析显示腺癌、ⅢB～Ⅳ期、D二聚体增高是肺癌发生静脉血栓的独立危险因素（P〈0．05）。结论肺腺癌、肿瘤晚期、D二聚体增高是肺癌合并静脉血栓的高危因素。

Objective To summarize the clinical data of 38 cases of lung cancer with venous thromboembolism （VTE）, and to analyze risk factors of lung cancer with VTE. Methods We reviewed the clinical data of patients with lung cancer who were diagnosed with VTE （38 cases） and without VTE （76 cases） from April 2010 to July 2015. Univariate analysis was conducted to determine the possible associated variables. Multivariate Logistic regression analysis was applied to explore risk factors of lung cancer with VTE. Results Univariate analysis showed adenoearcinoma, stageⅢ B- Ⅳ, increased D Dimmer, central venous indwelling catheter, increased CEA were risk factors of lung cancer with VTE （P〈0.05）. Multivariate Logistic regression analysis showed adenocarcinoma, stage Ⅲ B- Ⅳ, increased D Dimmer were independent risk factors of lung cancer with VTE （P〈0.05）. Conclusion Adenocarcinoma, stage Ⅲ B- Ⅳ, increased D Dimmer were important risk factors of lung cancer with VTE.