胺碘酮联合β受体阻滞剂对急性心梗并发快速心律失常患者心功能的影响

The effect of amiodarone combined with beta blocker on cardiac function in patients with acute myocardial infarction complicated with rapid arrhythmia

目的探讨胺碘酮联合β受体阻滞剂对急性心梗并发快速心律失常患者心功能的影响。方法选择我院2014年6月至2015年10月期间收治的108例急性心梗并发快速心律患者作为观察对象，将患者随机分为观察组和对照组，每组54例。对照组患者采用胺碘酮治疗，观察组患者采用碘酮联合β受体阻滞剂美托洛尔治疗。记录两组治疗前后的左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、射血分数（LVEF）及心率（HR）指标，并将各项心功能指标及临床疗效进行对比。结果对照组患者的总有效率为79．63％，明显低于观察组的96．30％，两组相比差异有统计学意义（P〈0．05）。两组患者治疗前LVEDD、LVESD、LVEF及HR相比均无统计学差异（P〉0．05）；治疗后观察组的LVEDD、LVESD及HR指标均低于对照组，而LVEF显著高于对照组，差异有统计学意义（P〈0．05）。结论胺碘酮联合β受体阻滞剂对急性心梗并发快速心律失常患者心功能的影响显著，可以明显提高临床治疗效果，改善患者心功能。

Objective To investigate the effect of amiodarone combined with beta blocker on cardiac function in patients with acute myocardial infarction complicated with rapid arrhythmia. Methods 108 cases of acute myocardial infarction complicated with rapid arrhythmia in our hospital from June 2014 to October 2015 were randomly divided into observation group and control group, 54 cases in each group. Control group was treated with amiodarone, observation group was treated with amiodarone combined with beta blocker （metoprolol）. Recorded left ventricular end diastolic diameter （LVEDD）, left ventricular end systolic diameter （LVESD）, ejection fraction （LVEF）, and heart rate （HR） of two groups before and after treatment, compared the indexes of cardiac function and clinical curative effect. Results The total effective rate in control group was 79.63%, significantly lower than 96.30% in observation group, with statistically significant difference between two groups （P〈0.05）. There were no statistically significant differences in LVEDD, LVESD, LVEF, and HR between two groups before treatment （P〉0.05）; after treatment, LVEDD, LVESD, and HR in observation group were significantly lower than those in control group, LVEF was significantly higher than that in control group, with statistically significant differences between two groups （P〈0.05）. Conclusion The effect of amiodarone combined with beta blocker on cardiac function in patients with acute myocardial infarction complicated with rapid arrhythmia is significant, which can significantly improve the clinical treatment effect and the cardiac function of patients.