曲安奈德益康唑联合丹参酮治疗面部脂溢性皮炎的临床疗效研究

Study on clinical effect of Pevisone combined with tanshinone in the treatment of facial seborrheic dermatitis

目的观察派瑞松联合丹参酮治疗面部脂溢性皮炎的临床疗效及安全性。方法120例面部脂溢性皮炎患者随机分为两组，对照组（n=60）仅采用派瑞松软膏治疗，观察组（n=60）采用派瑞松联合丹参酮进行治疗，两组疗程均为4周。观察两组治疗前后皮损程度、疗效及不良反应情况。结果观察组治疗总有效率显著高于对照组（96．7％vs．83．4％），差异有统计学意义（P〈0．05），治疗前两组（瘙痒、鳞屑、红斑及皮损）评分比较差异无统计学意义（P〉0．05），治疗后两组（瘙痒、鳞屑、红斑及皮损）评分较治疗前均显著降低，且观察组各种症状评分降低幅度显著大于对照组，差异有统计学意义（均P〈0．05），观察组不良反应发生率显著低于对照组（6．7％vs．16．7％），差异有统计学意义（P〈0．05）。结论派瑞松软膏联合丹参酮治疗面部脂溢性皮炎疗效显著，安全可靠，值得在临床上推广使用。

Oblective To observe the clinical efficacy and safety of Pevisone combined with tanshinone in the treatment of facial seborrheic dermatitis. Methods 120 cases of facial seborrheic dermatitis were randomly divided into two groups. Control group （n=60） was treated with Pevisone ointment, observation group （n=60） was treated with Pevisone and tanshinone, the course of treatment of two groups was 4 weeks. The degree of skin lesions before and after treatment, efficacy, and adverse reactions in two groups were observed. Results The total efficiency in observation group was 96.7%, and higher than 83.4% in control group, with statistically significant difference （P〈0.05）. There were no statistically significant differences in the scores of itching, scaling, erythema, the total score of skin lesions between two groups before treatment （P〉0.05）, the scores of itching, scaling, erythema, the total score of skin lesions in two groups significantly decreased after treatment, the extent of reduction in observation group was significantly greater, with statistically significant differences （P〈0.05）. The incidence of adverse reactions in observation group was significantly lower than that in control group （6.7% vs.16.7%）, with statistically significant difference （P〈0.05）. Conclusion Pevisone ointment combined with tanshinone in the treatment of facial seborrheic dermatitis has remarkable curative effect, safe and reliable, which is worth promotion and application in clinical.