外泌体微小RN A--肿瘤发生发展的新型调节分子

MicroRNAs in exsomes-the new-type of regulatory molecules in the tumor progression

肿瘤微环境是影响肿瘤细胞侵袭转移的关键因素，外泌体是微环境中细胞间信号交流的一种形式，微小RNA（miRNA）广泛参与了生物体多种生理过程，它们在肿瘤内环境稳定方面起着重要的作用。其中肿瘤外泌体中的miRNA具有诱导肿瘤细胞增殖，细胞外基质重塑，促进迁移、侵袭和肿瘤相关血管形成等功能。通过作用于外泌体产生和释放的机制，可阻断致癌基因的表达，为肿瘤的发生发展及治疗提供新的思路。

Tumor microenvironment is the key factor that influences the invasion and metastasis of tumor cells.Exosome is the particle by which cells can make communication in microenvironment.MicroRNA （miRNA）is widely involved in physiological processes,and plays an important role in the stability of tumor environment.MiRNAs in exosome play roles in tumor cell proliferation,extracellular matrix remodeling,and then promote the metastasis,invasion and angiogenesis of tumor.Thus,the expression of oncogenes can be blocked by regulating the exosome production and secretion.It may shed light on the development of a thera-peutic strategy for tumor treatment.