微小RN A-32在肝细胞癌中的作用

The role of microRNA-32 in hepatocarcinoma

微小RNA（miRNA）参与多种重要的细胞生物学过程，还参与包括肝细胞癌（HCC）在内的多种疾病的发生与发展。近年来研究发现miR-32在多种肿瘤组织中表达异常，miR-32在HCC中表达上调，扮演了“致癌基因”的角色，参与调控体内HCC细胞的细胞周期、凋亡及侵袭转移等多个病理生理过程，并有望成为HCC治疗的新靶点。

MicroRNAs （miRNA）play an important role in a variety of cellular biology processes,and participate in the occurrence and development of a variety of diseases including hepatocellular carcinoma （HCC）.In recent years,miR-32 has been shown to be aberrantly expressed in many tumor tissues.miR-32 is up-regulated in HCC and plays an oncogene role in regulating the cell cycle,apoptosis,invasion,metastasis and so on.MiR-32 maybe a potential target for HCC therapy.