新疆大肠癌与肿瘤标志物的相关性研究

Correlation between colorectal cancer and tumor markers in Xinjiang

目的探讨新疆大肠癌与肿瘤标志物的相关性。方法选取2013年7月至2016年7月间新疆医科大学第四附属医院收治的211例大肠癌患者的血清,采用电化学发光法测定血清中肿瘤标志物,分析不同性别、不同年龄、不同族别和不同部位以及发生肝转移前后肿瘤标志物的变化。分析单项检测和联合检测癌胚抗原(CEA)、CA125、CA724和CA153对大肠癌诊断的阳性率。结果女性患者血清中CA125水平较男性高,差异有统计学意义(P<0.05)。年龄≥70岁者血清中细胞角蛋白19片段(Cyfra21-1)的水平较<70岁者高,非汉族患者血清中CA153的水平较汉族高,差异均有统计学意义(均P<0.05)。大肠癌肝转移组患者血清中CA50、CEA、CA199和Cyfra21-1水平较未发生肝转移者高,差异均有统计学意义(均P<0.05)。联合检测多种肿瘤标志物可以提高检出阳性率,增加检测敏感性。结论肿瘤标志物可广泛用于肿瘤患者的早期诊断和预后判断,联合检测多种肿瘤标志物可提高敏感性,为大肠癌早期诊断提供依据。

Objective To explore the relationship between colorectal cancer and tumor markers in Xinjiang.Methods From July 2013 to July 2017,blood serum of 211 patients with colorectal cancer was collected at The Forth Affiliated Hospital of Xinjiang Medical University.By using electrochemical luminescence,serum tumor markers were measured and changes in the serum tumor markers of different gender,age,nationality and site before and after liver metastases were analyzed.The positive rate of carcinoembryonic antigen（CEA）,cancer antigen 125（CA125）,CA724 and CA153 by individual and joint detection in the diagnosis of colorectal cancer was analyzed.Results The level of CA125 in female patients was significantly higher than in males（P〈0.05）.The level of cytokeratin-19-fragment（Cyfra 21-1） in patients ≥70 years was significantly higher than in patients 70 years（P〈0.05）.The level of CA153 in the non-Han Chinese population was significantly higher than Han Chinese population（P〈0.05）.The level of serum CA 50,CEA,CA 199 and Cyfra 21-1 in patients with colorectal cancer metastatic to the liver were significantly higher than those without liver metastasis（all P〈0.05）.Joint detection can improve the positive rate and increased detection sensitivity.Conclusion Tumor markers can be widely used in the early diagnosis and prognosis of cancer patients,which can provide basis for early diagnosis of colorectal cancer.