基于细胞自噬机制的健康科学研究进展

Autophagy-based mechanistic understanding of healthcare science

自噬(autophagy)是细胞对自身组件进行降解与回收的自然过程,与人类健康高度相关。很多疾病都伴随着自噬的异常。本文回顾了国内外近年来在自噬与健康关系领域的研究,包括自噬与癌症、神经退行性疾病等疾病的关系。并且回顾了对人体健康有明显影响的电离辐射、体育锻炼、针灸、按摩等物理刺激对细胞自噬的调控作用,从自噬的角度对这些作用的分子机制进行了讨论。最后,对于自噬调控在未来的医疗保健中的潜在价值进行了展望。

Background： Autophagy is a natural process in cells for self-digestion of intracellular elements, which is highly related to human health. Purpose： To better understand the relationship between autophagy and health issues like cancer, neurodegeneration and aging, we reviewed recent studies on this topic in this paper. We also reviewed some physical stimulations that have effects on health while have been verified capable to induce autophagy, including ionic radiation, physical exercise, acupuncture and massage. Results ＆ Conclusion： We discussed the molecular mechanisms of their effects from the point of autophagy, and looked to the future of healthcare where the regulation of autophagy may be heavily involved.