摘要
In cardiac myocytes,the sarcoplasmic reticulum(SR)is the main storage organelle of free Ca^(2+).The concentration of free Ca^(2+)in the SR is 0.5–1.0 mmol/L and is 2–3 orders of magnitude greater than that in the cytosol.The SR is composed of interconnected cisternae(junctional SR,i.e.,JSR)and tubules(free SR network,i.e.,FSR)that extend throughout the cytosol[1].Ca^(2+)is released from the JSR into the cytosol via Ca^(2+)release units(CRUs,
In cardiac myocytes, the sarcoplasmic reticulum （SR） is the main storage organelle of free Ca2＋. The concentration of free Ca2＋ in the SR is 0.5-1.0 mmol/L and is 2-3 orders of magnitude greater than that in the cytosol.
基金
supported by the National Natural Science Foundation of China (11272014 and 11328201)
the National Key Basic Research Program of China (2013CB531200)
