摘要
EGFR抑制剂是抗肿瘤药物研究的热点,文章就近年来新合成的六元并五元环母核类EGFR酪氨酸激酶抑制剂进行综述总结,重点关注国内外已报道的药物骨架结构,简要论述一些抑制剂的结构以及构效关系研究,希望能为EGFR抑制剂后续的研发提供启示和参考。
Since the EGFR inhibitor has become one of the research hotspots in the development of anti-tumor drugs, the paper overviews various kinds of the newly synthesized EGFR inhibitors, and focuses on skeletons of the five-member ring fused with six-member ring, reported by world famous pharmaceutical companies and organizations, furthermore, briefly comments on the structure-activity relationships of some inhibitors, in order to make sense in the future design and research of EGFR inhibitors.
出处
《广东化工》
CAS
2017年第2期63-65,76,共4页
Guangdong Chemical Industry
关键词
表皮生长因子受体
酪氨酸激酶
六元并五元环
epidermalgrowth factorreceptor(EGFR)
Tyrosinekinase
five-and-six-memberedheterocyclic