丙硫菌唑中间体的合成优化

Optimization of the Intermediate of Prothioconazole

作为一种新型的三唑硫酮类杀菌剂,丙硫菌唑凭借其广谱的杀菌活性及低毒、安全、环保特性,目前已跃居全球第三大杀菌剂。但是,丙硫菌唑关键中间体的合成阻碍了原药的大量生产,主要对α-乙酰基-α-氯-γ-丁内酯和3,5-二氯-2-戊酮的合成进行了研究和优化,为原药的合成与生产做好铺垫。

As a new triazole fungicide sulfurketones, prothioconazole has some advantages of broad-spectrum bactericidal activity and low toxicity, safety and environmental protection, and has now become the third largest fungicide in the world. However, the synthetic process of the key intermediate of prothioconazole hindered the technical production. In this paper,the synthesis of α-chlorine- γ- acetyl-butyrolactone and 3, 5- dichloro-2-pentanone were studied and optimized to lay the foundation for the technical production.