同型半胱氨酸和脂蛋白a与冠心病的相关性研究

Research on correlation between homocysteine and lipoprotein with coronary heart disease

目的探讨血清同型半胱氨酸(Hcy)和脂蛋白a[Lp(a)]水平与冠心病的相关性研究。方法选取该院内科门诊及住院部冠心病患者152例作为试验组,试验组根据临床表现分为59例心律失常组和93例心肌缺血组,另外同期选取该院体检中心的151例非冠心病者作为对照组。采用免疫比浊法测定各组血清Hcy和Lp(a)水平并进行比较分析。结果心率失常组、心肌缺血组血清Hcy水平与对照组比较,差异有统计学意义(P<0.05);心率失常组、对照组的血清Lp(a)水平与心肌缺血组比较,差异有统计学意义(P<0.05)。结论有效控制血清Hcy和Lp(a)水平对冠心病的防治有重要的临床意义。

Objective To explore the correlation between serum homocysteine（Hcy）and lipoprotein a[Lp（a）]levels with coronary heart disease（CHD）.Methods One hundred and two outpatients and inpatients with CHD were selected as the experimental group and divided into the arrhythmia group（59cases）and myocardial ischemia group（93cases）according to the clinical manifestations.Contemporaneous 151 of non-CHD undergoing physical examination were selected as tne control group.The immune turbidimetric method was adopted to detect serum Hcy and serum Lp（a）levels.Then the detection results were performed the comparative analysis.Results Serum Hcy level had statistical difference between the arrhythmia group and myocardial ischemia group（P〈0.05）;serum Lp（a）level had statistical difference between the arrhythmia group and the control group with the myocardial ischemia group（P〈0.05）.Conclusion Effective control of serum Hcy and Lp（a）levels has an important clinical significance for the prevention and treatment of CHD.