脂质体镶囊的研究进展

Research Progress of Capsosomes

脂质体镶囊(capsosome)是利用层层自组装技术将脂质体包埋在聚电解质微囊的囊壁中,从而形成"夹层式"结构的囊泡,其与生物膜有着极好的相容性,并兼备聚电解质微囊和脂质体的双重优点,作为药物载体具有很大的优势。本文主要介绍脂质体镶囊的特点、制备方法及影响因素和负载的药物种类,为将药物制成脂质体镶囊提供更广泛的思路和选择。

Capsosomes, a new class of polymer capsules containing liposomes subcompartments, which preserve the advantages of both polyelectrolyte microcapsnles and liposomes while eliminating some of the shortcomings, are formed through the layer-by-layer （LBL） assembly of polymers and liposomes and expected to find diverse applications in biomedicine, especially for the creation of artifi- cial cells or organelles. In this review, the design and performance of capsosomes are mainly introduced, and capsosomes are pointed out to be a promising platform toward the creation of therapeutic artificial cells and organelles or as a novel approach for multiple drug delivery.